Synthesis,Characterization,and DNA Binding Properties of Dinuclear Copper(Ⅱ)Complex Cu2(TATP)2(L-Leu)2(CIO4)22°2H2O

摘要

A dinuclear copper(Ⅱ) complex [Cu2(TATP)2(L-Leu)2(ClO4)2]2·2H2O was synthesized and characterized,where,TATP=1,4,8,9-tetraazatriphenylene,and L-Leu=L-leucinate. The complex was crystallized in the triclinic space group P1,with two independent molecules in a unit cell. Two Cu(Ⅱ) ions in each complex [Cu2(TATP)2(L-Leu)2(ClO4)2] molecule were found to be in different coordination geometries,i.e.,Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of TATP,the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate,and Cu1 or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms,and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalative mode and cleave pBR322 DNA in the presence of ascorbate.