Key Laboratory of Structure-based Drug Design and Discovery;
Ministty of Education Shenvang Pharmaceutical University;
Shenyang 110016;
P.R.China;
Department of Bioengineering;
Zhuhai Campus of Zunyi Medical University;
Zhuhai 519041;
P.R.China;
Shengjing Hospital of China Medical University;
Shenyang 110016;
P.R.China;
Sorafenib; derivative; Tetrazole; moiety; Antitumor; activity;