The mission of the Chemical Process R&D Department at DuPont Pharmaceuticals Company is to supply drug substance in a timely fashion and to discover/develop a scalable, economical, environmentally friendly process for the commercial production of the bulk drug substance. Several examples will be presented to illustrate our effort to accomplish the mission. Brief discussion will include the following projects:1) Synthesis of DMP 728, a cyclic peptide of GP IIb/IIIa inhibitor 2) Method for the preparation of a-chloroboronic acid, a key intermediate for DuP 714,a potent thrombin inhibitor3) Process research and development of Roxifiban, a potent and orally active GP IIb/Illa inhibitor ……
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