A series of 2-amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinyl substituted diaryl urea derivatives was designed and synthesized.Their in vitro cytotoxicities against two cancer cell lines(Bel-7402 and A549) were evaluated by standard MTT assay.Six of tested compounds 6,8,10,17,21 and 22 exhibited more potent cytotoxicity superior to sorafenib.The structure activity relationship(SAR) study indicates that 2-amino-5,6,7,8-tetrahydropyrido- [4,3-d]pyrimidinyl group was an option for cytotoxic potency.
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