Key Laboratory of Structure-based Drug Design and D~covery;
Min~try of Education;
Shenyang Pharmaceutical University;
Shenyang 110016;
P. R. China;
State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug;
College of Chemical and Pharmaceutical Engineering;
Hebei University of Science and Technology;
Shijiazhuang 050018;
P. R. China;