α-四（4-羧基联苯氧基）酞菁钴的合成及抑制SGC-7901型胃癌细胞研究

摘要

以3-硝基邻苯二甲腈和4′-羟基联苯-4-羧酸为原料合成3-(4-羧基联苯氧基)邻苯二甲腈。 DBU催化法合成金属酞菁α-四(4-羧基联苯氧基)酞菁钴，用IR、UV-vis和LC-MS进行表征。测定α-四(4-羧基联苯氧基)酞菁钴在DMSO溶剂中以单体形式存在，利用MTT染色法确定了酞菁钴对杀伤SGC-7901细胞的杀伤作用和量效关系，当浓度达到80μg·mL-1时，酞菁钴抑瘤率达到78%。%This paper describes synthesized of 3- (4-carboxy-biphenyl-yloxy) phthalonitrile with 3-nitro-phthalonitrile and 4'-hydroxy-biphenyl-4-carboxylic acid as axial ligands. Synthesis of metal phthalocyanineα- tetra (4-carboxy-biphenyloxy) cobalt phthalocyanine in DBU catalyzed, IR,1H NMR and LC -MS spectra. Determination of α- tetra (4-carboxy-biphenyloxy) cobalt phthalocyanine to monomer form in DMSO solvent, i-dentified CoPc on SGC-7901 cell killing effect and dose-effect relationship by MTT staining, when concentration of 80 μg·mL-1 , CoPc inhibition rate reached 78%.