Multiomics:unraveling the panoramic landscapes of SARS-CoV2 infection

摘要

In response to emerging infectious diseases,such as the recent pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),it is critical to quickly identify and understand responsible pathogens,risk factors,host immune responses,and pathogenic mechanisms at both the molecular and cellular levels.The recent development of multiomic technologies,including genomics,proteomics,metabolomics,and single-cell transcriptomics,has enabled a fast and panoramic grasp of the pathogen and the disease.Here,we systematically reviewed the major advances in the virology,immunology,and pathogenic mechanisms of SARS-CoV-2 infection that have been achieved via multiomic technologies.Based on well-established cohorts,omics-based methods can greatly enhance the mechanistic understanding of diseases,contributing to the development of new diagnostics,drugs,and vaccines for emerging infectious diseases,such as COVID-19.