Advances and challenges of mesenchymal stem cells for pregnancy-related diseases

摘要

Mesenchymal stem cells(MSCs)with pluripotency,wide origin and strong migration ability,but low immunogenicity and lack of ethical controversies,have been intensely investigated for clinical applications within the last decades.Our previously published data in this issue of Cellular and Molecular Immunology demonstrated that adoptive transfer of MSCs can prevent fetal loss in lipopolysaccharide-induced and spontaneous abortion models via a paracrine effect and a cell contact-dependent manner.