CD81,a new actor in the development of preeclampsia

摘要

CD81 is a widely expressed transmembrane protein that provides a scaffold for signaling molecules and orchestrates interactions among membrane-associated proteins to initiate signaling cascades related to cell migration,adhesion,and fusion1.CD81 exerts a wide range of regulatory effects on immune cells.In B cells,CD81 facilitates the assembly of CD19-CR2/CD21 and B-cell receptor complexes at tetraspanin-enriched signaling microdomains,lowering the threshold dose of antigen required to trigger B-cell clonal expansion and antibody production.