Granulocyte-macrophage colony-stimulating factor:an immunotarget for sepsis and COVID-19

摘要

Granulocyte-macrophage colony-stimulating factor(GM-CSF),which belongs to the colony-stimulating factor(CSF)superfamily and was originally identified as a hemopoietic growth factor,is mainly produced by lymphocytes and innate lymphoid cells.Nonhematopoietic cell populations such as fibroblasts,endothelial cells,and epithelial cells may also secrete GM-CSF in response to an activating stimulus.