Improvement of a SARS-CoV-2 vaccine by enhancing the conjugation efficiency of the immunogen to self-assembled nanoparticles

Xiantao Zhang; Yaochang Yuan; Bolin Wu; Xuemei Wang; Yingtong Lin; Yuewen Luo; Rong Li; Tao Chen; Jieyi Deng; Xu Zhang; Fan Zou; Xin He; Hui Zhang

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Improvement of a SARS-CoV-2 vaccine by enhancing the conjugation efficiency of the immunogen to self-assembled nanoparticles

机译：通过提高免疫原的缀合效率对自组装纳米颗粒来改善SARS-COV-2疫苗

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To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to control the pandemic.Generally,nanoparticle(NP)vaccines can generate a more potent immune response than mRNA vaccines[2].

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《细胞与分子免疫学：英文版》 |2021年第8期|P.2042-2044|共3页
作者
Xiantao Zhang; Yaochang Yuan; Bolin Wu; Xuemei Wang; Yingtong Lin; Yuewen Luo; Rong Li; Tao Chen; Jieyi Deng; Xu Zhang; Fan Zou; Xin He; Hui Zhang;
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作者单位

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Qianyang Biomedical Research Institute Guangzhou Guangdong 510063 China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of Education Guangdong Engineering Research Center for Antimicrobial Agents and Immunotechnology Engineering Research Center of Gene Vaccines of the Ministry of Education Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 Guangdong China;

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原文格式 PDF
正文语种 chi
中图分类医学微生物学（病原细菌学、病原微生物学）;
关键词
vaccine; vaccines; assembled;

Improvement of a SARS-CoV-2 vaccine by enhancing the conjugation efficiency of the immunogen to self-assembled nanoparticles

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