Comment to: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

摘要

We have read with interest the article by Crinier et al.describing a comprehensive single-cell RNA sequencing dataset of human bone marrow natural killer(NK)cells from eight healthy donors.1 Their unbiased analysis resulted in the identification of three NK cell populations in bone marrow:hNK_Bm1,hNK_Bm2 and hNK_Bm3.These populations correspond to the NK cell populations that the authors previously described in human spleen:hNK_Spl1,hNK_Sp2 and hNK_Sp3.2 The authors compared the gene signatures of the three bone marrow populations to the conventional CD56bright and CD56dim NK cells in the blood and concluded that hNK_Bm1 cells resemble CD56dim NK cells,hNK_Bm2 cells correspond to CD56bright NK cells,and hNK_Bm3 represent a CD56bright tissue-resident NK cell population that is not present in the blood.