The germinal center(GC)reaction is considered the cornerstone of our humoral immune response.Localized in specialized follicles inside secondary lymphoid organs,germinal center B cells(GCBCs)execute a pivotal task.Following an infection,the number of GCBCs is rapidly expanded,and subsequently GCBCs differentiate into specialized antibody-secreting factories.This intricate process is driven by the positive selection of GCBCs via the B-cell receptor with the highest affinity for the respective antigen.During this period of extensive proliferation,GCBCs are among the fastest dividing cells in our body.It has been established that cell proliferation requires tremendous amounts of energy and building blocks.However,there remains a paucity of evidence to explain how proliferating GCBCs meet these metabolic demands.In their latest publication in Nature Immunology,Weisel et al.provided new insights that may have a far-reaching impact on the evolution of the immunometabolism field.
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