Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells

摘要

Interferons(IFNs)are“warning signal”cytokines released upon pathogen sensing.IFNs control the expression of interferonstimulated genes(ISGs),which are often crucial to restrict viral infections and establish a cellular antiviral state.1,2 Langerin(CD207),a well-known surface receptor on Langerhans cells(LC),belongs to the C-type lectin receptor(CLR)family and constitutes a major pathogen binding receptor able to regulate both innate and adaptive immune responses.3,4 Importantly,this CLR was reported as an antiviral receptor.