Relief of YAP-mediated inhibition by IKKε promotes innate antiviral immunity

摘要

The innate immune response to invading viruses is critical for the mounting of protective immunity,in which type I interferons(IFN),for example,IFN-αandβ,are potent effector molecules.1 Most cell types,particularly fibroblasts and epithelial cells,produce IFN-β,whereas hematopoietic cells,notably plasmacytoid dendritic cells,are the predominant sources of IFN-α.IFNs potently stimulate a variety of innate and adaptive immune cells,including macrophages,NK cells and T cells.The binding of type I IFN to its cognate receptor triggers the activation of the Janus kinase signal transducer and activator of transcription pathway,which results in the transcription of IFNstimulated genes that play key roles in host resistance to viral infections.