High-level intrinsic disorder explains the universality of CLIP binding to diverse MHC class II variants

摘要

MHC class I and II molecules bind peptides that are either recognized as self or as foreign to the immune system via interaction with T-cell receptors.The T-cell receptor makes molecular contacts with the peptide and the MHC molecule in the region of the MHC peptide binding cleft.The MHC class I and II molecules are highly polymorphic,which presumably allows for great diversity of antigen-binding sites over the population,leading to a species that is relatively fit to withstand foreign pathogens.In MHC class I molecules,this allelic variation predicts extensive variation in the sequence of peptides able to bind MHC class I molecules,and this is indeed the case.