Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway

著录项

• 来源
  《细胞与分子免疫学：英文版》 |2017年第6期|P.529-545|共17页
• 作者

  Rong Wang12; Aizhang Xu1; Xueying Zhang12; Jie Wu1; Andrew Freywald3; Jianqing Xu4; Jim Xiang125;

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• 作者单位

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

  [1]Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 [2]School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [3]Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 [4]Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China [5]Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5;

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• 收录信息
• 原文格式 PDF
• 正文语种 chi
• 中图分类 辐射的防止与修复;
• 关键词

  CD40L; CTLs; 慢性感染; 信号通路; T细胞; 细胞毒性T淋巴细胞; 疫苗; 衰竭;

  机译：CD40L;CTLs;慢性感染;信号通路;T细胞;细胞毒性T淋巴细胞;疫苗;衰竭;