Novel Role and Regulation of the Interleukin-1 Receptor Associated Kinase（IRAK）Family Proteins

摘要

＜正＞ The interleukin-1 receptor associated kinases（IRAKs）sit at the bottle neck for the Toll-like-receptor（TLR）mediated signal transduetion process controlling host innate immune response.However,the exact role andregulation of IRAKs are still in the early stage and not fully understood.This review intends to summarize therecent advancement in this important topic and points out areas that need further intensive investigation.Cellular＆ Molecular Immunology.2005:2（1）:36-39.