Group 3 innate lymphoid cells: intestinal patrolling guardians bullied by T cells

摘要

Since the discovery of group 3 innate lymphoid cells(ILC3s),many studies have reported that,in addition to T cells,ILC3s also play an indispensable role in intestinal immune surveillance,host defense,and homeostasis[1].Although both ILC3s and T cells regulate intestinal inflammation through the secretion of interleukin(IL)-22,differences in the behaviors of these two cell types,especially the dynamic shift and mechanism of ILC3 regulation between normal and inflammatory states,remain unclear.A recent paper by Jarade et al.[2]published in Nature Immunology reported that intestinal ILC3s under basal conditions are immotile and arrested in the presence of T cells.Furthermore,the environmental T cells,the microbiota,and the chemokine CCL25 jointly shape ILC3 patrolling behavior and their effector function of maintaining intestinal barrier integrity via IL-22.These findings facilitate the study of ILC biodynamics and ILC immune regulation and the search for therapeutic strategies for gastrointestinal diseases.