Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models

摘要

CD8^(+)effector T(T_(E))cells play a critical role in immunity against infections.In response to a pathogenic stimulus,antigenpresenting cells(APCs)deliver three signals[via T-cell receptor(TCR),costimulation,and cytokines]to naive CD8^(+)T cells,stimulating their entry into a developmental program characterized by T-cell expansion followed by a contraction phase.During the contraction phase,90-95%of IL-7R^(-)CD62L^(-)KLRG1^(+)T_(E)cells undergo cell apoptosis.