Multiple death pathways in TNF-treated fibroblasts:RIP3-and RIP1-deoendent and independent routes

摘要

Dear Editor, Tumor necrosis factor-α(TNF)can induce either apoptosis or programmed necrosis(necroptosis)when different cell lines are used[1,2].While receptorinteracting protein 1(RIPI)can participate in signaling for both apoptosis and necrosis[3,4],recent studies by us and by others have shown that RIP3 is essential for TNF-induced necroptosis[5-7] and has no role in TNFinduced poptosis[6,7].Classification of TNF-induced cell death in a number of cell lines,such as L929 and murine embryonic fibroblasts(MEFs),has been made based on morphological and/or biochemical parameters [2,7-10].