Canine transmissible venereal tumor genome reveals ancient introgression from coyotes to pre-contact dogs in North America

摘要

Dear Editor, Canine transmissible venereal tumor (CTVT),the oldest known somatic cell line,is a living fossil of the original founder,transmitted from host's cancer cells to other canids during the mating process.1 Since it was shown ten years ago that living cells from an ancient host could be transmitted among canids,the origin of CTVT has been studied continuously2.Recent comparison of the CTVT genetic data with a more comprehensive canine reference panel including pre-contact dogs (PCDs) from North America argued that the CTVT founder (the original canid infected with CTVT) is the closest detectable lineage to PCDs,and that this clade underwent introgression from wild canids in North America.3