PML Gene, arsenic and apoptosis of leukemic cells

摘要

Acute promyelocytic leukaemia (APL) has been attracting a wide interest far beyond hematological field in the last dozen years due to the presence of specific chromosome tranlocations and clinical responsibility to all-trans retinoic acid (ATRA) by differentiation induction as well as to arsenic trioxide (ATO). Most (95%) APL patients carry specific chromosome translocation t(15;17), which leads to discovery of PML gene on chromosome 15. Such a translocation causes the fusion of PML to retinoic acid