Human lung fibroblast express acetylcholinesterase during apoptosis in vitro

摘要

Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. AChE is also found in tissues devoid of cholinergic responses, indicating its potential function beyond neurotransmission. It has been suggested that AChE may participate in development, differentiation, and pathogenic processes such as Alzheimer's disease and tumorigenesis. We examined AChE expression in human lung fibroblast cell line (HLF) upon induction of apoptosis by UV or G418. AChE is induced in all apoptotic cells examined as determined by cytochemical staining, immunological analysis,