The Krüppel traffic report: Cooperative signals direct KLF8 nuclear transport

摘要

@@ The Krüppel-like transcription fac-tor (KLF) family consists of 17 dis-tinct family members involved in the regulation of diverse cellular processes including differentiation, cell prolifera-tion, growth-related signal transduction, angiogenesis and apoptosis (recently reviewed in [1]). In addition to their currently known biologic roles, the discovery that at least one member of the family, KLF6, can be alternatively spliced into biologically active isoforms with antagonistic functions and a dis-tinct subcellular localization pattern [2], highlights the fact that nuclear-cytoplasmic shuttling of KLF proteins may represent an additional layer of functional regulation and the possibility of an even more diverse and completely unexplored role for KLF family mem-bers in both health and disease.