Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30

摘要

Dear Editor,Histone H3 lysine 4(H3K4)methylation is closely correlated to gene transcription activation[1].In mammals,the MLL family(also called KMT2)histone methyltransferase,which includes MLL1 to 4,SET1A,and SET1B,are the principal enzymes that carry out the global methylation of H3K4 in vivo[1].In contrast to other SET domain-containing histone methyltransferases,MLL family proteins exhibit very low intrinsic histone methyltransferease(HMT)activity by themselves.Their full activity is only achieved in the presence of WDR5,Ash2L,RbBP5,and DPY30,the common regulatory components of all MLL family complexes[2].