The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells

摘要

Dear Editor, In eukaryotes,increased protein folding demand at the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) [1],which plays a pivotal role in control of cellular functions and survival under ER stress [2].Chronic ER stress is thought to contribute to the pathogenic progression of diabetes [3,4].Inositol-requiring enzyme 1 (IRE 1),an ER-resident transmembrane Ser/Thr protein kinase and endoribonuclease,is the most conserved ER stress sensor that mediates a key branch of the UPR [1].