Phosphorylated ubiquitin: a new shade of PINK1 in Parkin activation

摘要

The Parkinson's disease (PD)-associated proteins,Parkin and PINK1,together comprise a mitochondrial quality control pathway that promotes neuronal survival through autophagy of damaged mitochondria.Three recent studies have found that Parkin recruitment to mitochondria and ubiquitin ligase activity is controlled by the phosphorylation of ubiquitin by PINK1.