Drosha and Dicer: Slicers cut from the same cloth

摘要

DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor,which is essential for microRNA biogenesis.A recent study by Kwon et al.in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8,thereby unveiling the topology and interactions between components of the Microprocessor and insights into its ‘ruler’-based cleavage activity and function.