m6A RNA modification controls autophagy through upregulating ULK1 protein abundance

摘要

Dear Editor, N6-methyladenosine (m6A) is the prominent dynamic mRNA modification,governed by methyltransferase complex ("writers"),demethylases ("erasers") and RNA-binding proteins ('readers').1 m6A modification directs mRNAs to distinct fates by grouping them for differential processing,translation and decay in the processes such as cell differentiation,embryonic development and stress responses.1,2 Owing to a deeper understanding of this modification and the technological advance,functional characterizations of m6A in gene regulation have become a hot topic that warrants further dissection.3,4