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首页> 外文期刊>临床病例讨论杂志(英文版) >Relationship between bronchial asthma and glucocorticoid receptor gene bcl-I single nucleotide polymorphism
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Relationship between bronchial asthma and glucocorticoid receptor gene bcl-I single nucleotide polymorphism

机译：支气管哮喘与糖皮质激素受体基因bcl-1单核苷酸多态性的关系

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机译：Objective: To investigate the relationship between bronchial asthma in children and glucocorticoid receptor (GR) gene bcl-I single nucleotide polymorphism and to analyze the relationship between bronchial asthma and the plasma cortisol level. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques were used to deter-mine the GR gene bcl-I single nucleotide polymorphism in 76 children patients with asthma and 50 healthy controls. The plasma cortisol levels were detected by radio immunoassay in two groups respectively. Results: There were three genotypes found in bcl-I gene locus of these two groups, which were genotype CC, GG and CG. The frequencies of CC, CG, GG genotypes were 48.7%, 27.6%, 23.7% in the asthma group and 76%, 20%, 4% in the control group. The difference was of statistical significance (p < .05). The frequency of G allele in the asthma group was 37.5%, which was significantly higher than 14% in the control group (p < .05), indicating that G allele was associated with asthma. Conclusions: GR gene bcl-I polymorphism is significantly associated with the occurrence of bronchial asthma. G allele may be a susceptibility gene for steroid-resistance in asthma. Steroid-resistance has no correlation to the plasma cortisol level.

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