Alkaline phosphatase flare with hyperostosis of bone metastases in lung adenocarcinoma treated with gefitinib

摘要

Alkaline phosphatase (ALP) lfare has been reported to occur during cancer treatment as a favorable event, particularly in the presence of bone metastasis. There have been only a few reports in lung cancer and associated radiographic ifndings have seldom been described. The authors observed ALP lfare in a female patient with lung adenocarcinoma soon after the initiation of geiftinib. Moreover, on computed tomography, metastatic lesions of the rib and thoracic spine showed marked hyperostosis, with sizes larger than the original bone structure, suggesting efifcacy of geiftinib. The signiifcance of such hyperostosis should be elucidated.