Hepatocellular carcinoma in HCV - liver cirrhosis before and after successful DAA treatment

摘要

Chronic hepatitis C virus(HCV)infection is a major cause of liver cirrhosis and hepatocellular carcinoma(HCC)worldwide.The recent advancement of direct-acting Antiviral Agents(DAAs)in hepatitis C therapy,resulted in sustained virological response rates of over 90%in treated patients in different stages of liver fibrosis.The efficacy of DAAs treatment has also been confirmed in real-life cohorts that include subjects with decompensated cirrhosis and therefore seems a promising step to a significant reduction in the recurrence of HCC in patients who achieved complete destruction of the HCC nodules by local therapy.We present a 72-year old patient with HCV-related liver cirrhosis who successfully responded to DAAs treatment after complete destruction of an early HCC nodule.