首页> 外文期刊>肝癌研究(英文版) >Chitinase-3-like protein 1 as a predictor for the progression or regression of liver fibrosis
【24h】

Chitinase-3-like protein 1 as a predictor for the progression or regression of liver fibrosis

机译:几丁质酶3样蛋白1可预测肝纤维化的进展或消退

获取原文
获取原文并翻译 | 示例
       
机译:Liver fibrosis is a wound-healing response of liver cells to chronic injuries caused by viral infections, including hepatitis B virus (HBV), hepatitis C virus (HCV), toxins, and alcohol abuse. The ability to stage diseases for treatment na?ve patients to initiate proper medical procedures and predict the clinical causes of the disease or the treatment response is important given the increased prevalence of liver fibrosis caused by HBV, HCV and fatty liver diseases. CHI3L1 (chitinase-3-like protein 1, also known as YKL-40), which belongs to the chitinase family but lacks chitinolytic activity and is highly expressed in the liver, seems to fulfill this role. CHI3L1 is a non-invasive staging marker for liver fibrosis caused by HBV, HCV and non-alcoholic fatty liver disease as well as a predictor of the clinical causes and fibrotic changes after treatments. CHI3L1 predicts histological progression of liver fibrosis and fibrosis progression rate (fibrosis unit/year), rapid fibrosis progression after liver transplantation and response to interferon and recent direct acting antiviral therapy in chronic HCV patients. CHI3L1 also predicts response to antiviral therapy in chronic HBV patients.

著录项

  • 来源
    《肝癌研究(英文版)》 |2018年第8期|P.81-86|共6页
  • 作者单位

    [1]Zhejiang-California International Nanosystems Institute(ZCNI)Proprium Research Center Zhejiang University Hangzhou310058 Zhejiang Province China;

    [2]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Af.liated Hospital School ofMedicine Zhejiang University Hangzhou310058 Zhejiang Province China;

    [3]University of Washington School of Medicine Seattle WA98195 USA;

    [4]Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou310020 Zhejiang Province China;

    [5]Department of Liver Diseases The Second Hospital of Yunnan Province Kunming650000 Yunnan Province China;

    [6]The Third People’s Hospital hospital of Changzhou Changzhou213001 Jiangsu Province China;

    [7]Virology Department Armed Forces Institute of Pathology Block E-16 New Cob Lane Javed Sultan Shaheed Colony RawalpindiCantt Rawalpindi Pakistan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 内科学;
  • 关键词

    CHI3L1; liver fibrosis; progression; regression; hepatitis B virus; hepatitis C virus; treatment response;

    机译:CHI3L1;肝纤维化进步回归乙型肝炎病毒;丙型肝炎病毒;治疗反应;
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号