Exosome-based liquid biopsy in the management of hepatocellular carcinoma

Aparna Jayachandran12; Sasidhar Venkata Manda3; Ritu Shrestha12; Kim R.Bridle12; Prashanth Prithviraj4; Darrell H.G.Crawford12

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Exosome-based liquid biopsy in the management of hepatocellular carcinoma

机译：基于外来体的液体活检在肝细胞癌的治疗中

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机译：Hepatocellular carcinoma (HCC) commonly presents at an advanced stage due to the lack of efficient early screening tools. Early, non-invasive biomarkers useful in the diagnosis and prognosis of HCC would be of significant benefit for HCC management. Development of exosome-based liquid biopsy as a non-invasive method for the management of HCC has gained much traction. Exosomes are small membranous vesicles secreted by most cell types including HCC cells. Exosomes serve as couriers for the intercellular transfer of important biomolecules, including, protein, nucleic acids and lipids to nearby and distant cells in the body. The molecular cargos carried by exosome have been described to play significant roles in cancer progression. Herein, we will dissect how HCC-derived exosomes confer aggressive traits such as tumour growth, invasion, immune remodelling and drug resistance to HCC cells. We review the current literature concerning exosomes as biomarkers in a diagnostic setting, evaluating their prognostic, predictive and monitoring capabilities. This review will highlight and discuss emerging research in the utility of exosome-based liquid biopsies therapeutic tools in HCC management. Here we will also focus on advances in exosome biology in preclinical studies.

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《肝癌研究(英文版)》 |2018年第8期|P.48-59|共12页
作者
Aparna Jayachandran12; Sasidhar Venkata Manda3; Ritu Shrestha12; Kim R.Bridle12; Prashanth Prithviraj4; Darrell H.G.Crawford12;
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作者单位

[1]School of Clinical Medicine The University of Queensland Brisbane QLD4072 Australia;

[2]Gallipoli Medical Research Institute Greenslopes Private Hospital Brisbane QLD4120 Australia;

[3]Apollo Hospitals Educational and Research Foundation Hyderabad Telangana500096 India;

[4]Fiona Elsey Cancer Research Institute Ballarat VIC3350 Australia;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Hepatocellular carcinoma; liquid biopsy; exosomes; microRNA; epithelial-to-mesenchymal transition; cancer stem cell;

机译：肝细胞癌;液体活检外泌体微小RNA;上皮到间质转化;癌症干细胞;

Exosome-based liquid biopsy in the management of hepatocellular carcinoma

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