Oxidative stress and hepatocarcinogenesis

Ying Fu1; Fung-Lung Chung2

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Oxidative stress and hepatocarcinogenesis

机译：氧化应激与肝癌发生

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机译：Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. There are two major challenges for HCC, the first being that early detection is generally not applicable, and secondly, it is usually fatal within several months after diagnosis. HCC is an inflammation-induced cancer. It is known that chronic inflammation leads to oxidativeitrosative stress and lipid peroxidation, generating excess oxidative stress, together with aldehydes which can react with DNA bases to form promutagenic DNA adducts. In this review, the evidence between oxidative stress and liver carcinogenesis is summarized. We focused on the potential of using DNA adducts as oxidative stress biomarkers for liver carcinogenesis.

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来源
《肝癌研究(英文版)》 |2018年第8期|P.1-8|共8页
作者
Ying Fu1; Fung-Lung Chung2;
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作者单位

[1]Laboratory of Molecular Biology Center for Cancer Research NCI Bethesda MD20892 USA;

[2]Lombardi Comprehensive Cancer Center Georgetown University Washington DC20007 USA;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Oxidative stress; DNA adduct; hepatocellular carcinoma; prevention; hepatocarcinogenesis;

机译：氧化应激DNA加合物;肝细胞癌;预防;肝癌发生;

Oxidative stress and hepatocarcinogenesis

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