Preliminary Study on the Expression and the Significance of S-Phase Kinase Associated Protein 2 in Atypical Ductal Hyperplasia and Breast Cancer

摘要

OBJECTIVE To explore the relationship of high S-phase kinase associ- ated protein 2 (Skp2) expression with the characteristics of breast cancer. METHODS Using a immunohistochemical method, Skp2 expression was detected and evaluated in 30 normal tissues, 30 atypical ductal hy- perplasias (ADH), 30 ductal carcinomas in situ (DCIS) and 56 invasive carcinomas (including invasive specific carcinoma and invasive nonspe- cific carcinoma). The relationship between Skp2 expression and the characteristics of breast cancer was analyzed. RESULTS Skp2 expression varied among normal tissue, ADH, DCIS and invasive carcinomas (χ2=54.02, P<0.005). The positive level of Skp2 ex- pression in DCIS was higher than that of normal tissue (χ2=21.82, P< 0.005) and there was a significant difference in Skp2 between DCIS and ADH (χ2=5.08, P<0.025) as well as between invasive carcinomas and DCIS (χ2=6.52, P<0.01). The positive expression level of Skp2 in invasive carcinomas with positive lymph nodes was remarkably higher compared to those with negative lymph nodes. A significant difference in Skp2 ex- pression was found between combined histological Grades I and II ver- sus Grade III of invasive carcinomas (χ2=6.66, P<0.01). CONCLUSION High Skp2 expression may play an important role in car- cinogenesis and biological behavior of breast cancer.