Histone Deacetylase Inhibition: An Important Mechanism in the Treatment of Lymphoma

摘要

Lymphomas encompass a group of malignancies that originate in the lymph nodes or other lymphoid tissues.Epigenetic modification, especially by histone deacetylase(HDACs),plays a key role during the occurrence and development of lymphomas.Consequently, HDAC inhibitors(HDACIs),a class of gene expression-modulating drugs,have emerged as promising mechanism-based agents for the treatment of lymphomas.This review presents the rationale of HDAC inhibition,describes the epigenetic-based mechanisms of action of HDACIs,discusses their clinical efficiency,and summarizes the current and future developments in this field.