In human, the skin is one of the organs that exhibit early-onset aging-associated dysfunction. As a critical physical barrier, the skin is composed of a variety of cell types including fibroblasts and keratinocytes. Due to its high heterogeneity, it is difficult to accurately reveal the cell type-specific molecular mechanisms of human skin aging, which hinders our understanding of human skin aging and the development of interventions for human skin aging and related diseases.
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