One Step Closer Towards Complete Bioproduction of Zocor

摘要

Simvastatin(Zocor)i s one of the most pharmaceutically important cholesterol-lowering drugs with annual sales exceeding$3 billion in2015.The industrial production of simvastatin usually includes three steps:microbial production of lovastatin through Aspergillus terreus fermentation,alkaline hydrolysis of lovastatin to produce monacolin J。