Cyclophilin A-regulated Ubiquitination Found Critical for RIG-I-mediated Antiviral Immune Responses

摘要

Cyclophilin A(CypA,encoded by PPIA)is a peptidyl-prolyl cis/trans isomerase(PPIase)that is expressed ubiquitously in all type of cells.CypA is the major cellular target for the immunosuppressive drug cyclosporin A(CsA)and is involved in protein folding,cell signaling,inflammation,and tumorigenesis.Recent work suggests that it