RANKL-RANK signaling regulates osteoblast differentiation and bone formation

摘要

In the recent two decades, it has been well elucidated that receptor activator of nuclear factor-κB ligand (RANKL;also known as TNFSF11) binding to its receptor RANK (also known as TNFRSF11A) drives osteoclast development as the crucial signaling pathway.1-3 However, accumulating evidence also implies that osteoblastic RANKL regulates osteoblastogenesis.4-6 The studies “RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation” by Chen et al.