Early pregnancy loss,defined as a nonviable intrauterine pregnancy occurring before 12 weeks of gestation,is estimated to affect 25%of clinically diagnosed pregnancies[1].Several demographic,lifestyle,and environmental risk factors have been reported to associate with the risk of early pregnancy loss,yet the causes of most early pregnancy losses remain elusive;thus,further studies are needed.Perfluorinated compounds(PFCs)are a class of widespread environmental pollutants that can adversely affect human reproductive health.Humans are inevitably exposed to PFCs through diet,water,air and dust.A wealth of epidemiological and toxicological research using a variety of animal models has warned of the persistence,bioaccumulation,and toxicity of PFCs[2].
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机译:Fendas orofaciaisnorecém-nascido eo uso de medicamentosecondiçõesdesaúdematerna:estudo caso-controle na cidade do Rio de Janeiro,Brasil Oral clefts in the newborn and in medical intake and maternal health conditions:the case-control study study巴西里约热内卢