X-盒结合蛋白1的生理及病理生理学作用

摘要

X-box binding protein 1 (XBP-1) is an important component of unfolded protein response. XBP-1 has two splicing variants designated spliced XBP-1 (XBP-1S) and unspliced XBP-1 (XBP-1U) respectively. During endoplasmic reticulum stress, XBP-1 is induced by ATF6 and spliced by IRE1, thereby generated functional XBP-1S and activating unfolded protein response. As an important transcription factor, XBP-1 plays important roles in the regulation of cell growth and differentiation and is involved in the genesis and development of human diseases.%X-盒结合蛋白1(XBP-1)是未折叠蛋白反应的重要组分,有剪接型XBP-1(XBP-1S)和非剪接型XBP-1(XBP-1U)两种形式.当细胞处于内质网应激状态时,XBP-1由活化转录因子6(ATF6)诱导,经IRE1α非传统剪接,转录有功能的XBP-1S,活化未折叠蛋白反应.XBP-1是一种重要的转录因子,对细胞生长和分化具有重要调控 作用,并与人类多种疾病的发生和发展相关.