正电子核素标记Annexin V的研究进展

摘要

Annexin V is a protein that highly binds to exposed phosphatidylserine (PS) on apoptosis cells and non-invasive positron emission computed tomography (PET) imaging of apoptosis in vivo may have important implications for clinical practice, assisting in early detection of disease* monitoring of disease course, assessment of treatment efficacy, or management of personlized patients. This review provides a critical and thorough overview of the development of Annexin V labeled with positron emitting nuclides and in vivo evaluation of apoptosis-detecting PET radiopharmacueticals that have emerged so far, along with their possible applications in nuclear medicine.%Annexin V是一种磷脂结合蛋白,能与细胞凋亡过程中翻转到膜外的磷脂酰丝氨酸(PS)特异性结合,因此Annexin V是检测细胞早期凋亡的灵敏指针.利用正电子核素对Annexin V进行标记后,通过与PS的结合可检测细胞凋亡,实现活体无创正电子发射计算机断层显像(PET),从而进行人体细胞凋亡研究,达到疾病早期诊断的目的.本文就正电子核素标记Annexin V用于凋亡显像的研究现状进行综述.