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Ebola virus disease: past, present and future

机译:埃博拉病毒病:过去,现在和未来

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Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate(up to 90%) accompanying with the disease. Ebola haemorrhagic fever(EHF) is an infectious disease of animal that can be transmitted to both human and non-human primates. The first epidemic of EHF occurred in 1976 in the Democratic Republic of the Congo. The incubation period of ebola is less than 21 days. Ebola virus infections are depicted by immune suppression and a systemic inflammatory response that leads to damage of the vascular, coagulation and immune systems, causing multi-organ failure and shock. Five genetically distinct members of the Filoviridae family responsible for EHF are as follows: Zaire ebolavirus, Sudan ebolavirus, C?te d’Ivoire ebolavirus, Bundibugyo ebolavirus and Reston ebolavirus. The ongoing 2014 West Africa ebola epidemic has been considered as the most serious panic in the medical field with respect to both the number of human cases and death toll. The natural host for ebola virus is unknown, thus it is not possible to carry out programs to regulate or abolish virus from transmission to people. The ebola virus infection provides little chance to develop acquired immunity causing rapid progression of the disease. It is pertinent to mention that at present, there is no antiviral therapy or vaccine that is helpful against ebola virus infection in humans. The impediment of EHF necessitates much better understanding of the epidemiology of the disease, particularly the role of wildlife, as well as bats, in the spread of ebola virus to humans.
机译:埃博拉病毒病是伴随人类死亡的高死亡率(高达90%),是人类已知的最致命的疾病之一。埃博拉出血热(EHF)是一种动物传染病,可同时传播给人类和非人类灵长类动物。 EHF的首次流行于1976年在刚果民主共和国。埃博拉病毒的潜伏期少于21天。埃博拉病毒感染表现为免疫抑制和全身性炎症反应,导致血管,凝血和免疫系统受损,导致多器官衰竭和休克。负责EHF的Filoviridae家族的五个遗传上不同的成员如下:扎伊尔埃博拉病毒,苏丹埃博拉病毒,科特迪瓦埃博拉病毒,本迪布吉埃博拉病毒和雷斯顿埃博拉病毒。就人类病例数和死亡人数而言,持续进行的2014年西非埃博拉疫情被视为医学领域最严重的恐慌症。埃博拉病毒的天然宿主是未知的,因此不可能执行程序来调节或废除病毒向人的传播。埃博拉病毒感染提供了很少的机会发展获得性免疫力,从而导致疾病的快速发展。值得一提的是,目前还没有抗病毒疗法或疫苗可帮助抵抗人类的埃博拉病毒感染。 EHF的障碍需要更好地了解该病的流行病学,尤其是野生生物以及蝙蝠在埃博拉病毒向人类传播中的作用。

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