Objective:To study the differences between the lipid profiles of the subjects whose parents are having known non-modifiable risk factors such as obesity,hypertension(HTN),myocardial infarction and diabetes,and compare them with the lipid profiles of the subjects whose parents are not having those risk factors.Methods:A total of 402 subjects were recruited to this study.A detailed questionnaire which included information on the past medical history,height,weight,blood pressure,physical activity,smoke,alcohol,family history of coronary heart disease,HTN.diabetics and obesity.Basic demographic data and dietary habits were completed by all participants.Blood samples were obtained from all subjects after 14 h.Lipid profiles were analyzed using automated analyzer.The results were analyzed using SPSS software packages.Results:The mean body mass index of the population was well below the cut-off value of obesity(24.5 kg/m") and high risk of future cardiovascular disorder(CVD) events in this age group.The mean levels of total cholesterol(TC),triglycerides(TG) and TC/high density lipoprotein(HDL) were less than the risk levels indicative of future CVD events according to the ATP Ⅲ cut-off values.However the mean HDL level in our population was slightly greater than the cut-off value while the mean low density lipoprotein level was almost similar to the risk level.Differences were observed when the subjects without history of maternal obesity were compared with subjects with history of maternal obesity.The greater percentage of subjects who are having risk levels of body mass index.TC.low density lipoprotein.TG.and TC/HDI.indicated that maternal obesity contributed to the greater susceptibility of developing CVD risk in their offspring.Conclusions:Advancing age may result in changes that could be atherogenic in the future.Such atherogenic changes have already initialed when the subjects are about 21 years old.The incidence of atherogenic changes is far greater when mothers who are having any of the risk factors such as obesity,diabetes,HTN and myocardial infarction than that fathers who are havine similar risk factors.
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机译：目的：研究父母具有肥胖，高血压（HTN），心肌梗塞和糖尿病等不可改变的危险因素的受试者的脂质谱的差异，并将其与父母为肥胖的受试者的脂质谱进行比较。方法：本研究共招募了402名受试者。详细的问卷包括过去的病史，身高，体重，血压，体力活动，烟，酒，冠心病家族史的信息。疾病，HTN，糖尿病和肥胖症）所有参与者均完成了基本的人口统计学数据和饮食习惯.14小时后从所有受试者中采集血样。使用自动分析仪分析脂质概况，并使用SPSS软件包对结果进行分析。该人群的平均体重指数远低于肥胖的临界值（> 24.5 kg / m“），并且未来该人群发生心血管疾病的风险较高ge组。根据ATPⅢ临界值，总胆固醇（TC），甘油三酸酯（TG）和TC /高密度脂蛋白（HDL）的平均水平低于指示将来发生CVD事件的风险水平。我们人群中的HDL水平略高于临界值，而平均低密度脂蛋白水平几乎与危险水平相似。将没有母体肥胖病史的受试者与有母体肥胖病史的受试者进行比较，发现差异。体重指数，低密度脂蛋白，TG / HDI风险水平较高的受试者百分比表明，母亲肥胖导致其后代患心血管疾病的可能性更大。导致未来可能发生动脉粥样硬化的变化。当受试者大约21岁时，此类动脉粥样硬化的变化已经开始。 o与那些具有相似危险因素的父亲相比，患有肥胖，糖尿病，HTN和心肌梗塞等任何危险因素。
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