Antidiabetic and antidiarrhoeal effects on ethanolic extract of Psidium guajava(L.) Bat.leaves in Wister rats

摘要

Objective:To evaluate the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Psidium guajava leave(EEPGL) in Wisier rais to support its traditional uses.Methods:Oral glucose tolerance test model and alloxan induced diabetic test model were performed to evaluate antidiabetic activity of EEPGL at doses of 1.00.0.50 and 0.75 g/kg respectively.For antidiarrhoeal effects of EEPGL.castor oil-induced diarrhoea model and gastrointestinal motility test with barium sulphate milk model were also assessed at doses of750.500 and 250 mg/kg.respectively.Results:Administration of EEPGL at doses 1.00 and 0.50 g/kg significantly(P0.05)decreased blood glucose levels in oral glucose tolerance test model as well as 0.75 g/kg dose in alloxan induced diabetic test model in Wister rats(P0.001).Application of EEPGL at doses of 750 and 500 mg/kg showed antidiarrhoeal effect in castor oil-induced diarrhoeal model(P0.00 l and P0.01,respectively),and 750 mg/kg(P0.01),500 and 250 mg/kg(P0.05)doses in barium sulphate milk model in aforesaid animals.Conclusions:These results exhibited the significant antidiabetic and antidiarrhoeal activities of ethanolic extracts of Psidium guajava leave in Wister rats.