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Sperm counts and sperm sex ratio in male infertility patients

机译:男性不育患者的精子数量和精子性别比

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摘要

In recent years,investigators have noted a trend toward a declining proportion of male births in many industrialized nations.While men bear the sex-determining chromosome,the role of the female partner as it pertains to fertilization or miscarriage may also alter the gender ratio.We attempted to determine a man's secondary sex ratio (F1 generation) by directly examining the sex chromosomes of his sperm.We examined our male infertility clinic database for all men who had undergone a semen fluorescence in situ hybridization (FISH).Patient demographic and semen parameters were recorded.Chi-squared analysis was used to compare gender ratios (Ychromosomes/total chromosomes).Multivariable logistic regression was used to predict the odds of possessing a Y-bearing sperm after accounting for demographic and semen parameters.A total of 185 men underwent sperm FISH.For the entire cohort,the proportion of Y chromosome-bearing sperm was 51.5%.Men with less than five million motile sperm had a significantly lower proportion of Y chromosome-bearing sperm (50.8%) compared to men with higher sperm counts (51.6%; P=0.02).After multivariable adjustment,a higher sperm concentration,total motile sperm count and semen volume significantly increased the odds of having a Y chromosome-bearing sperm (P<0.01).As a man's sperm production declines,so does the proportion of Y chromosome-bearing sperm.Thus,a man's reproductive potential may predict his ability to sire male offspring.
机译:近年来,研究人员注意到,在许多工业化国家中,男性出生比例呈下降趋势。尽管男性拥有决定性别的染色体,但女性伴侣在受精或流产方面的作用也可能改变性别比例。我们试图通过直接检查男性精子的性别染色体来确定其次要性别比(F1代)我们检查了男性不育诊所数据库中所有进行过精液荧光原位杂交(FISH)的男性。记录参数,使用卡方分析比较性别比(染色体/总染色体),使用多变量logistic回归分析人口和精液参数后预测拥有Y精子的几率。总共185名男性进行了FISH精子检查。在整个队列中,Y染色体精子的比例为51.5%。活动精子少于500万的男性有显着性意义。与具有较高精子数量(51.6%)的男性相比,具有Y染色体的精子比例显着较低(50.8%; P = 0.02)。经过多变量调整后,较高的精子浓度,活动精子总数和精液量显着增加了带有Y染色体的精子的几率(P <0.01)。随着男人精子产量的下降,其比例也随之降低。因此,一个人的生殖潜能可能预示着他的雄性后代的能力。

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  • 来源
    《亚洲男性学杂志(英文版)》 |2012年第5期|683-686|共4页
  • 作者单位

    Department of Urology,Stanford University School of Medicine, Stanford, CA 94305, USA;

    Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA;

    Department of Urology, Brown University, Providence, RI 02912, USA;

    Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA;

    Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA;

  • 收录信息 中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
  • 原文格式 PDF
  • 正文语种 chi
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  • 入库时间 2022-08-19 03:40:45
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