Pharmacological effects of aqueous-ethanolic extract ofHibiscus rosasinensis on volume and acidity of stimulated gastric secretion

摘要

Objective:To explore the effects of extract ofHibiscus rosasinensis (H. rosasinensis) on the volume, free and total acidity of gastric secretion induced by carbachol.Methods: Animals were kept on fasting for48 h, then the pylorus of each animal was ligated. They were randomly divided into5 groups and treated by carbachol at 600 μg/kg. Then animals in group Ⅱ-Ⅴ were treated byH. rosasinensis extract at 250 and500 mg/kg body weight, cimetidine at 2.5 mg/kg and verapamil at 10mg/kg body weight intraperitoneally, respectively. The volume, free and total acidity of gastric secretion were observed and compared.Results: It was found that the extract significantly reduced the volume, free and total acidity of gastric secretion (P<0.01). These reductions were comparable to cimetidine and verapamil. And the reduction in the volume and free acidity were more significant in cimetidine and verapamil treated group indicating that cimetidine and verapamil were more effective.Conclusions:The extract ofH. rosasinensis can reduced the volume, free and total acidity of gastric secretion, and can be used effectively in the treatment of peptic ulcer.